Ubushakashatsi bushya buteza imbere imyitozo iteza imbere ubusore

Urupapuro ruherutse gusohoka mu kinyamakuru cya Physiology rwakajije umurego ku ngaruka ziteza imbere ubusore imyitozo ngororamubiri ku binyabuzima bishaje, yubakiye ku mirimo yabanjirije iyakozwe n'imbeba za laboratoire yegereje iherezo ry'ubuzima bwabo busanzwe bwashoboraga kubona uruziga ruremereye.

Urupapuro rurambuye, "Umukono wa molekuline usobanura imyitozo yo kurwanya imihindagurikire y'ikirere no gusaza no muri vivo igice cya porogaramu mu mitsi ya skeletale," urutonde rw'abanditsi 16, batandatu muri bo bafitanye isano na U ya A. Umwanditsi uhuye ni Kevin Murach, umwungirije wungirije muri U ishami ry’ubuzima, imikorere y’abantu n’imyidagaduro, naho umwanditsi wa mbere ni Ronald G. Jones III, impamyabumenyi y'ikirenga.umunyeshuri muri Murach's Molecular Muscle Mass Regulation Laboratory.

Kuri iyi mpapuro, abashakashatsi bagereranije imbeba zishaje zashoboraga kubona uruziga ruremereye hamwe nimbeba zagiye zisubiramo porogaramu ya epigenetike hakoreshejwe uburyo bwa Yamanaka.

Ibintu bya Yamanaka ni ibintu bine byandikirwa kuri poroteyine (byamenyekanye nka Oct3 / 4, Sox2, Klf4 na c-Myc, bikunze kuvugwa muri OKSM) bishobora gusubiza ingirabuzimafatizo zisobanutse neza (nk'akagari k'uruhu) zisubira mu ngirabuzimafatizo, ari a leta ntoya kandi ihuza n'imiterere.Igihembo cyitiriwe Nobel muri Physiology cyangwa Medicine cyahawe Dr. Shinya Yamanaka kubera uku kuvumbura mu mwaka wa 2012. Mu kigero gikwiye, gutera ibintu bya Yamanaka umubiri wose mu nzoka birashobora guhindura ibimenyetso biranga ubusaza bigana imiterere ihuza n'imiterere ihuriweho n'abasore benshi selile.

Mubintu bine, Myc iterwa no gukora imitsi ya skeletale.Myc irashobora kuba nk'ibisanzwe biterwa no kongera porogaramu mu mitsi, bigatuma iba ingingo y'ingirakamaro yo kugereranya ingirabuzimafatizo zagiye zisubirwamo hifashishijwe uburyo bwo kwerekana ibintu bya Yamanaka n'ingirabuzimafatizo zagiye zandikwa binyuze mu myitozo ngororamubiri - “gusubiramo porogaramu” mu rubanza rwa nyuma byerekana uburyo ibidukikije bitera ibidukikije birashobora guhindura uburyo bwo kwerekana imiterere ya gen.

Abashakashatsi bagereranije imitsi ya skeletale yimbeba zari zemerewe gukora imyitozo itinze mubuzima n imitsi ya skeletale yimbeba zakabije OKSM mumitsi yabo, ndetse nimbeba zahinduwe genetique zigarukira gusa gukabya gukabije kwa Myc gusa mumitsi yabo.

Ubwanyuma, itsinda ryemeje ko imyitozo iteza imbere imiterere ya molekuline ijyanye na gahunda ya epigenetike igice.Nukuvuga ko: imyitozo irashobora kwigana ibintu bigize imiterere ya molekuline yimitsi yagiye ihura nibintu bya Yamanaka (bityo bikagaragaza ibimenyetso biranga selile nyinshi zurubyiruko).Ingaruka zingirakamaro zimyitozo ngororamubiri zishobora kwitirirwa ibikorwa byihariye bya Myc mumitsi.

Nubwo byoroshye gutekereza ko umunsi umwe dushobora gukoresha Myc mumitsi kugirango tugere ku ngaruka zimyitozo ngororamubiri, bityo bikaturinda akazi gakomeye, Murach aratuburira ko byaba ari umwanzuro utari wo gufata.

Ubwa mbere, Myc ntizigera ishobora kwigana ingaruka zose zo hepfo imyitozo ifite mumubiri.Ninimpamvu yibibyimba na kanseri, kubwibyo rero hari akaga kavukire mugukoresha imvugo yacyo.Ahubwo, Murach yibwira ko gukoresha Myc bishobora gukoreshwa nkingamba zigerageza kugirango wumve uburyo bwo kugarura imihindagurikire yimyitozo ngororamubiri imitsi ishaje yerekana ko ititabira neza.Birashoboka ko bishobora no kuba uburyo bwo kwishyuza imyitozo yimyitozo yabashinzwe icyogajuru muburemere bwa zeru cyangwa abantu bafungiwe kuruhuka kuryama bafite ubushobozi buke bwo gukora siporo.Myc ifite ingaruka nyinshi, nziza cyangwa mbi, bityo gusobanura ibyiza bishobora kuganisha kumiti itekanye ishobora kugirira akamaro abantu mumuhanda.

Murach abona ubushakashatsi bwabo nko kwemeza imyitozo nka polypill.Agira ati: "Imyitozo ngororamubiri niwo muti ukomeye dufite."

Abanditsi ba Murach na Jones muri U ya A barimo umwarimu w’imyitozo ngororamubiri Nicholas Greene, ndetse n’abashakashatsi batanze umusanzu Francielly Morena Da Silva, Seongkyun Lim na Sabin Khadgi.